Enzymes in Brief

  • Porcine Pancreatic Replacement Enzymes needed with every meal. NO treats in-between meals.
  • Powdered enzymes are preferred, BUT they are not necessarily available in all parts of the world and may not be suitable for all dogs. Others are available (enteric coated, granules, tablets, raw, etc.) some of which are well established and some others that may work via trial and error. See list on this page.
  • "Suggested" dose of powdered enzymes (USA products):  1 level tsp per 1 cup kibble (with liquid added)
  • Heat destroys enzymes, Cold inhibits enzyme activity
  • When using powdered enzymes, not necessary BUT advisable to incubate 20/+ minutes with slightly warm liquid to avoid "possible" mouth sores
  • DISCOUNT ENZYMES! "Enzyme-Diane Enzymes" http://www.enzymediane.com/ generic food grade enzymes available at less than 1/2 cost of pharmaceutical grade enzymes used for years by many on this website/EPI forum members
  • A list of various European Enzyme products potency/and Tylan metric conversion guide for EPI patients outside of the USA
  • Scroll to bottom of page for Enzyme Research and research on canine gastric enzymes

Various Enzyme product types and their proper Application


The convenient method of treatment for EPI is with porcine replacement enzymes (not enzyme supplements). These enzymes are needed to break down all foods that a dog ingests. Although raw pancreas is considered as a viable treatment, raw pancreas is not always obtainable, hence the preference for pancreatic replacement enzymes.

If you live outside the USA, please check with your vet if any of the porcine-based enzyme products listed below are available in your country.

Enzyme potency in the USA is measured in USP units
(this is a different measurement than elsewhere in the world).
The necessary 3 ingredients (enzymes) with any EPI enzyme product are porcine-based
Lipase, Protease & Amylase.
If you live outside the USA and are trying to determine the proper amount of enzymes to use, please share these USA USP Units with your vet or pharmacist and have them work with you on determining the proper amount.

In the USA, the potency of the "powdered" porcine-based replacement enzyme may range from:

33,600 to 71,400 USP of Lipase (needed to digest fats and oils)
280,000 to 495,000 USP of Protease (needed to digest proteins)
280,000 to 495,000 USP of Amylase needed to digest carbohydrates)
Most often, the initial recommended dose is 2.8 grams or 1 teaspoon of enzymes with each meal (approximately 1 cup of food) . But talk to your vet- -they need to determine what the proper dose is for your individual dog. Beware... many "over-the-counter enzyme supplement" products do not supply enough of the proper amount of enzymes needed for an EPI dog. When determining what product to use, talk to your vet and/or other EPI dog owners.

FEEDING RAW PANCREAS:  If you would like to try using raw pancreas;  fresh beef, pork or lamb pancreas are recommended. Raw BEEF Pancreas is available for purchase in the USA at http://www.hare-today.com/  or http://www.greentripe.com/ , and new resource as of 2012 on the USA eastern coast is  http://www.greencuisine4pets.com/products.htm . There is also an amazing selection of raw pancreas at: https://www.mypetcarnivore.com/ . As of 2013 there is a raw bovine, porcine & ovine distributor, "BPOPARTS LLC" in Utah email at: [email protected]  , or if you are in the U.K. http://rawtogo.co.uk/ . One to three or four ounces of raw pancreas can replace one teaspoon of pancreatic extract. Raw pancreas may be frozen in cubes for future use and thawed naturally, but never heat on the stove or in the microwave. 

If possible beef or lamb raw pancreas is recommended over pork pancreas because of the "possibility" of the transmission of pseudorabies, although rare.

Also... raw pancreas is not all the same.  Each and every gland has a different potency of enzymes.  This is not just species to species.  The potency can vary from one farm animal to another farm animal as well. If you use 1 ounce of raw pancreas with the batch you are currently using the next batch may need to be tweaked. Fresh pancreas has a shelf life (in the freezer) of up to 3 months.

Tutorial on Feeding Raw Pancreashttp://www.epi4dogs.com/apps/forums/topics/show/8719995-how-to-feed-raw-beef-pancreas-a-photo-tutorial-?page=last

POWDERED ENZYMES may be kept in tightly sealed double plastic bags and then in a sealed container in the refrigerator to lengthen the longevity of the stored enzyme. However, it is very important that the enzymes be kept dry since moisture ruins the enzymes. Powdered enzymes shelf life (approximately 2 years).

ENZYMATIC ACTIVITY in humans ..Pancreatic enzyme secretion increases rapidly in response to a meal up to 6-fold above inter-digestive levels and reaches maximal values within 20?60 min post-prandially (after a meal).12 Enzyme output decreases thereafter to a 3- to 4-fold sustained increase, which is maintained for 3?4 h before returning to inter-digestive levels. This post-prandial pattern means that a maximal output of 3000?6000 IU/min lipase and a mean output of 2000?4000 IU/min lipase occur after ingestion of a normal mixed meal in healthy subjects.12 Enzyme substitution therapy should be able to mimic this pattern in situations of pancreatic exocrine insufficiency. (cited by J Enrique Domínguez-Muñoz "EPI Diagnosis & Treatment", Feb 16, 2011) .
Because a dog's digestive system is slightly different than a humans, we estimate that approximately 1-2 hours after an enzymed meal the inter-digestive levels return to normal.

ENZYME TABLETS do not appear to work as well other products such as the powders or even enteric coated capsules, however, if crushed, they may work..it depends on the individual dog.

PORK ALLERGY Alternatives:  Universally it is suggested to try Beef (bovine) Enzymes. Contact EnzymeDiane (USA) for beef powder, or see below for various raw pancreas sources, or do a search on beef enzymes on the internet; start with a double dose and increase as needed, usually need to play around with the dose/product until you find a workable solution. If there is an allergy to both pork (porcine) and beef (bovine) enzymes, Try sheep (ovine) enzymes. If in the USA, you can contact one of the raw pancreas suppliers, if you are outside the USA, you can try the whole gland sheep (ovine) capsules available on Amazon.com " Allergy Research Group - Pancreas Lamb 425mg, 90vcaps. By Allergy Research Group by Allergy Research:

 Also.... if your dog truly has a PORK ALLERGY.....depending on the severity of the allergy, you can continue to give the pork enzymes along with an antihistamine (prescribed by your vet), or you can try beef, lamb or even ox bile enzymes, and as a last resort... you can try plant enzymes. If your dog is a confirmed EPI dog..... any or all of these substitutes "might" help to one degree or another (no guarantees) but you will have to use much more than what is recommended to compensate for the insufficient potency.  With regards to possible plant enzymes, two products have been used that we know of with some success in dogs with true pork allergies:  TotalZymes http://www.k9medicinals.com/pet-products/digestive-support/total-zymes  and Dr. Goodpet http://www.goodpet.com/dogs/canine-digestive-enzymes/

HOWEVER.... we strongly advise not using these alternative unless your dog has a confirmed pork allergy.  Almost 99% of the time, when an owners swears the pet has a pork allergy (without being tested to confirm this) it turns out to be something else...... 


If, for whatever reason, you have an emergency and need enzymes ASAP ... the following are some links to over-the-counter enzymes, that although not the EXACT potency recommended, these enzymes are very close to the desired amount and should sustain your dog until you can secure the appropriate enzymes:


Once an EPI dog is stable, the goal is to reduce the amount of enzymes given to the smallest dose possible without causing a flare-up.


In AUSTRALIA There are three varying strengths of CREON® available in Australia, 10,000, 25,000 & 40,000. What is recommended as a starting point is to use one Creon 10,000 per meal (not per cup as recommended with porcine pancreatic powders only available overseas), except for miniature dogs in which case you might want to start with half the contents of one Creon 10,000 capsule.  Creon 10,000 is available without a prescription from pharmacies. Creon 25,000 and 40,000 are only available with a prescription from your vet. You may then choose to have the prescription filled at a discount pharmacy. If you are in Australia, please read the regularly updated ?EPI Management for Australian Dogs? brochure on the Downloads page: http://www.epi4dogs.com/downloads.htm Note: In October 2015, we became aware of another prescription pancreatin product called PANZYTRAT® 25,000 that is almost identical to Creon 25 000. This may also be an option (more information as it comes to hand).

If you decide on pancreatin CREON capsules (please share with your vet!):
For a much discounted CREON you can try either: 
www.chemistdirect.com.au or  www.chemistwarehouse.com.au or www.chemistking.com.au 

BIOCASE V made by Thomas Labs, 800-359-8387. Available from Amazon

BPOPARTS LLC. USDA raw Bovine, Porcine and Ovine parts that service Medical, Pharmaceutical & Research industries.  For raw pancreas... please contact Randy Feser at [email protected] or you can call him directly at 1-435-770-3132 (Utah)  http://www.biosciregister.com/BPO_Parts_LLC/Supplier/sid3870.htm

CHEMEYES  porcine pancreatin powder for Uk members  at very reasonable rates. Visit the http://www.chemeyes.co.uk/ and/or contact the proprietor, Cameron,  directly at [email protected] (see below for a full description)

CREON (available in  Australia, Canada, Europe, South America, the UK & the U.S)


These are enteric coated microspheres of enzymes encased in capsules. These capsules may be given whole or sprinkled on food if served immediately. Alternately, some people find that after giving Creon waiting for a period (5, 10 or 15 minutes) before feeding is more effective. Every dog is different and experimentation is required to find the most effective method. Please note: if you are going to sprinkle the contents ensure that the dog eats the entire meal so that all of the Creon is ingested. If in doubt, give the capsule whole before trying the sprinkling method.

CREON is commonly used in many places outside the U.S.  Existing CREON enzyme capsule products vary from region to region with not all strengths available in all regions. The can come in 5 , 10  , 20 strengths and new strengths approved as of 2009 of 6, 12, 24 strengths are becoming more readily available mainly in the US.  When initially treating an EPI dog, it is recommended to start with CREON 12 or CREON 10 which has 10,000 USP of Lipase, 37,500 USP of Protease, 33,200 USP of Amylase. There is some latitude using Creon as its effectiveness is dependant on the dog's pH level (you do not need to test for this) so getting the exact strength is not strictly necessary.

The CREON the potency measurement comparison is as follows:

CREON 10 Composition : 150 mg Pancreatin
Amylase 8,000 PhEur units (BP Units) also equals 33,400 USP units
Lipase 10,000 PhEur units (BP Units) also equals 10,000 USP units
Protease 600 Ph Eur units (BP units) also equal 37,500 USP units

CREON 25 Composition : 300 mg Pancreatin
Amylase 18,000 PhEur units (BP Units) also equals 74,700 USP units
Lipase 25,000 PhEur units (BP Units) also equals 25,000 USP units
Protease 1,000 Ph Eur units (BP units) also equal 62,500 USP units

However... please know, once you start with a particular brand of CREON and it works... DO NOT SWITCH brands!!!! "There are so many variables with prescriptions for CREON from different countries  Different countries fill the CREON differently. It is not regulated like medicine for hypertension etc.    Changing from one CREON made by Abbott opposed to Mylan as an example will vary very much.  It is strongly suggested that when you use a particular CREON made by a particular company .... stick with the one and do not try to use or vary them from one company or the another unless the amounts are exactly the same as you  have been using and working for your pet. 

If you are interested in purchasing CREON on-line..... one of our EPI FORUM members, Frank, put together a fabulous Northern Hemisphere database on CREON including the brand name, website address, the cost of the CREON, shipping costs, and breakdown of price per capsule. This PDF is a wealth of information. Although these prices are as of April 2010 and may fluctuate with the exchange rate and/or price change.. it will give you a snapshot of price and availability. Please feel free to check it out. Click on: CREON pricing-3a.pdf

A 2012 Research Study on the use of enteric coated enzymes (CREON, LYPEX, etc) for EPI dogs: 

Giving CREON is not straight-forward.... the pet owner will have to trial and error to find the right dose and the right administration technique.  The following is a little guidance on how to do this:


The trick to giving CREON is make sure that its activation starts at the right time while going thru the digestive system- -and that will depend on each dog's very own pH level in their digestive tract / small intestine.. So.... it is all based on what your dog's pH level is, not his size nor the amount of food given.... and this is why it takes a little trial and error with these dogs when placed on CREON.:)


First.... the dose.  We suggest starting with a CREON 10,000 per meal (you can add more if this amount doesn't work)

Next... the technique.... the best way is to just try the following techniques to see which works best ... and that is determined by the poo quality:


1. Give the CREON 10,000 capsule whole or sprinkle the contents and feed immediately or wait for 10 minutes before feeding (some dogs respond better with either method). Watch the poo for a few days and try to assess. Please note: if you are going to sprinkle the contents ensure that the dog eats the entire meal so that all of the Creon is ingested. If in doubt, give the capsule whole before trying the sprinkling method.


2. if the above does not produce optimal poo results, then you can try 2 x CREON 10,000 capsules. Watch the poo for a few days and try to assess if this helped, or if it is just right or not working at all....


3. if the above is not working at all.... then try giving a CREON 10,000 capsule about 5 minutes prior to a meal... again, watch the poo and try to assess if this appears to work better than the above or not.  If it does appear to work better.... but  still isn't perfect, then try giving the CREON 10,000 about 10 minutes prior to a meal and again assess the poo over the next few days.


These are some techniques... the trick in giving CREON will be up to you to try and figure out TWO THINGS!

1. what is the best "timing" method of giving CREON.. whole in capsules or in some cases whether opened and served immediately or 5, 10 or 15 minutes prior to a meal.


2. and then the right "dose"... whether one CREON 10,000 is enough or if you need two CREON 10,000... or if your dog is going to need approximately CREON 25,000 .


Cotazym (Pancrelipase) is the same as Creon http://www.drugs.com/mtm/cotazym.html


ENZYPLEX POWDER (Australia only) Enzyplex Powder for Dogs is an Australian made plant-based enzyme supplement for mild digestive conditions only. It is NOT a treatment for EPI and has been deregistered as a treatment for EPI from the Australian Pesticides and Veterinary Medicines Authority (APVMA) at the request of its manufacturer (deregistration date: April 2016).

 It contains insufficient amounts of enzymes required for normal digestion and is not a replacement for a functional pancreas. It is not potent enough to fully address the EPI condition and over time may encourage SID/SIBO to proliferate if used in this way. If your Australian vet recommends Enzyplex for EPI in the first instance you are STRONGLY encouraged to share the information contained in this brochure with your vet. CREON is the recommended commercial product capable of successfully treating EPI in companion animals in Australia.

It contains insufficient amounts of enzymes required for normal digestion and is not a replacement for a functional pancreas. It is not potent enough to fully address the EPI condition and over time may encourage SID/SIBO to proliferate if used in this way. If your Australian vet recommends Enzyplex for EPI in the first instance you are STRONGLY encouraged to share the APVMA deregistration advice with your vet. CREON is the recommended commercial product capable of successfully treating EPI in companion animals in Australia.


ENZYME-DIANE: GENERIC PANCREATIN (available in the US but can be shipped to certain countries outside of the US) Many people on the EPI FORUM use these generic enzymes for a savings of anywhere between 30-50%. If you are interested in ordering bulk-priced supplemental pork-based enzymes manufactured in the US, they can be directly purchased from http://www.enzymediane.com/ 


 (EnzyneDiane also generously donates enzymes to rescue and shelter organizations 
and gifts donated enzymes to those in need)


  • Pancreatin 6x10  (batch from 3/25/10)
    Lipase 70,840 USP units, Protease 448,000 USP units, Amylase 512,000 USP Unit.  COST:  8 oz for $42, 1 kilo for $134  (shipping included)
  • Pancreatin 8x10
  • Lipase 111,720 USP units, Protease 579,600 USP units, Amylase 694,400 USP Unit.  COST:  8 oz for $52, 1 kilo for $154  (shipping included)
    For Your Information:   1 kilo = 35.274 ounces

    There are 357 teaspoons in a kilo of 6x since a teaspoon is 2.8 grams of powder. 

    Since a teaspoon of powder is 2.8 grams ¾ tsp is 2.1 grams so 476 1 teaspoon equivalents in a kilo of 8x. 
EPIZYME8  made by V.E.T. Pharmaceuticals, 800-766-7543 http://www.allivet.com/

EUROBIOL (available in France)  http://drugs-about.com/drugs-e/eurobiol.html

GREEN TRIPE - Raw Ground Beef Pancreas   http://www.greentripe.com/

Green Tripe is located on the west coast  (California) of USA and their counter-part, GreenCuisine4Pets.com is located on the east coast (Georgia).... please see their link below.

GREEN CUSINE 4 PETS - Raw Ground Beef Pancreas

http://www.greencuisine4pets.com/  GreenCuisine4Pets.com is located on the east coast (Georgia) and is the counter-part of Green Tripe located on the west coast (California) .... please see their link above.

HARE TODAY - Raw Ground Beef Pancreas   http://www.hare-today.com/

  • Ground Beef pancreas (can be used as an alternative to pork enzymes) $2.29 per pound. Click on Raw Pet Foods and then select "Organ meats" 
LYPEX (available in England and Europe)  is an enzymatic concentrate derived from the porcine pancreas gland, available in capsules, must be opened and sprinkled on food. Do not incubate on the food. The purified and concentrated pancreatic enzymes are made into micro-pellets and each pallet is enteric-coated. This gives 100% protection to the enzymes from the damaging degradative acids present in the stomach.

Within ten minutes of the pellets passing the stomach to the alkaline environment of the small intestine the protective enteric coating dissolves and releases the protected enzymes to maximize digestion.

From the Manufacturer: Due to the enteric coating, we do not recommend premixing Lypex granules with water. Please apply the granules directly the food for consumption, as this ensures protection of the enzymes and therefore efficacy. As Lypex is tasteless, hopefully this should not affect palatability for your pet. 

Kind regards and thank you for your enquiry,


     Lauren Davis


     International Technical Adviser

     M: + 44 (0) 7525986487

     E: [email protected]

PANCRE PLUS  Vet One, NDC #13985-051-77, Qty 500 pills. Mfg by NEOGEN Corp, Dist by MWI in Meridan ID 1-888-694-8381
Tablet minimum: Lipase 9000, Protease 57000, Amylase 64000, Vitamin A 1000, VitaminD3 100, VitaminE 10.
Price can vary (1000 pills for $128-$160) discuss with vet.... EPI dog usage (each dog dose may vary) crush approximately  3 pills and sprinkle on each meal.

PANCREA-TABS PLUS  by Butler Animal Health Supply NDC# 11695-1235-7
Tablet minimum: Lipase 9000, Protease 57000, Amylase 64000, Vitamin A 1000, VitaminD3 100, Vitamin E 10.
500 pills approximately $95. EPI dog usage: crush approximately (each dog dose may vary) 3 pills and sprinkle on each meal.

PANCREATIC ENZYME SUPPLEMENT  by Partnar Animal Health (as of 12/16/2011 available in Canadahttp://www.partnaranimalhealth.ca//product_info.php?cPath=184&products_id=682&osCsid=cb0218985b4d36546fcc32a570c0a6c5
Pharmaceutical Grade porcine replacement enzymes. 15% more powder per package (131g) at the same price as  competitors with 114g pack size.
his product is available through veterinarians and now available through internet-based pet pharmacies in Canada.

Please go to this link to order: http://thepetpharmacy.ca/content/pancreatic-enzyme-supplement

Lipase      67,200 USP Units
Protease 280,000 USP Units
Amylase 280,000 USP Units
This is the ONLY Pharmaceutical-Grade powdered porcine enzyme manufacturer that is supporting EPI Research. A percentage of all sales will be donated to the EPI Genetic Research being conducted at Clemson University in South Carolina, USA by Drs. Leigh Anne Clark and Kate Tsai.
Partnar Animal Health is also helping EPI Awareness by including an EPI Brochure with each package of enzymes it sells. THANK YOU Partnar Animal Health!


PANAKARE PLUS  Enzymatic concentrate derived from the porcine pancreas gland with serum concentrations of fat soluble vitamins A, E &D. made by Neogen Corp, 800-477-8201   http://www.drugs.com/vet/panakare-plus-powder.html


PANCREATIC ENZYME a porcine pancreatic replacement enzyme for EPI dogs available in Canada soon to be available on-line


PANCREASE-V  a porcine pancreatic replacement enzyme for EPI dogs mfg in Canada
however... this product may be  purchased for $60 per 114 gram bottle through http://www.crossborder-pet-services.com/

(FOR CANADIAN CUSTOMERS:  The above mentioned company has just started a new on-line company to specifically serve the needs of Canadian clients..feel free to check out:  The Pet Pharmacy ? http://thepetpharmacy.ca/

The are selling Pancrease V - $62.16 per 114g jar, Tylan - $50.54 per 100g Jar and $44.36 per 250ml bottle )

PANCREOFLAT is an enzyme product available in India http://www.medindia.net/drug-price/pancreatin/pankreoflat-170plus80.htm


Pankreoflat 170 mg
22,825 USP units of amylase
6,500 USP units of lipase

Pankreoflat 170 mg: 22,825 USP units of amylase; 6,500 USP units of lipase; 25,000 USP units of protease 

Pankreoflat 170 mg
22,825 USP units of amylase
6,500 USP units of lipase
25,000 USP units of protease
22,825 USP units of amylase
6,500 USP units of lipase
25,000 USP units of protease
Pankreoflat 170 mg
22,825 USP units of amylase
6,500 USP units of lipase
Pankreoflat 170 mg
22,825 USP units of amylase
6,500 USP units of lipase
25,000 USP units of protease

PANCREZYME is an enzymatic concentrate derived from the porcine pancreas gland, available in powder form. made by Virbac Animal Health, 800-338-3659

PANCREX (available in the UK)  enteric coated capsules http://www.vetuk.co.uk/index.php?main_page=product_info&products_id=37

 Pancreatin BP to provide enzymatic activity per gram not less than:

  • Free protease 1400 BP units
  • Lipase 25000 BP units
  • Amylase 30000 BP units

If so.... you need to "try" 2 level teaspoons or 2.5 level teaspoons of this powder per 1 cup of food (dry food) add in approximately 1/4 cup of warm (not hot) water..... mix and let this food, water and enzyme sit for 20 minutes... mix again and then serve. Make sure this enzyme powder is not cold (stored in the frig) it needs to be room temperature... Try this for 3-5 days and see if things (poop) is looking good.....


PANK-AID ( available in Canadahttps://www.drugs.com/vet/pank-aid-can.html

PANZYME made by Aristavet  http://www.aristavet.co.uk/ (available in the UK)  

PROTEXIN  (Available in the UK )  http://www.viovet.co.uk/Protexin_Pro-Enzorb_for_Dogs/c21473/   
or http://www.vetimed.co.uk/en/pet/product/protexin-pro-enzorb-pack-of-60/

480mg Pancreatin enteric-coated micro-pellets: 

  •  Lipase ? 27,050 Ph. Eur. U. (minimum)
  • Amylase ? 22,604 Ph. Eur. U. (minimum)
  • Protease ? 1,325 Ph. Eur. U. (minimum)
  • Enterococcus faecium (NCIMB 10415) E1707 ? 1 x 108 CFU
  • Cyanocobalamin (Vitamin B12) ? >1mg


As of February 2015.... a new enteric coated porcine enzyme product will be available in Spain and Latin American countries.  The product is called "SUP-ENZIM" touted to be 41% less expensive then brand name enzymes for dogs and cats. 

To read about this product...please click here:  Spain_LatinAmer SUP-ENZIMS.pdf

Please contact Dr. Jordi Gimeno, Veterinario directly via email ([email protected]) for availability .. or check to see if it is listed yet at JG Global: http://www.jglobal.com.es/quienes-somos/

Contact options

(+34) 637 551 254

C / Hort de la Vila, 38 1-2 08017 Barcelona 

RAW-TO-GO Fresh raw pancreas available in the U.K.  http://rawtogo.co.uk/ . Please ask for Lesley Osbourne, located at:

The WarehouseMarket Street
MonmouthshireNP7 5SD
Telephone: 01873 268086

(Available in the UK )   http://www.vetuk.co.uk/index.php?main_page=product_info&products_id=164

VIOKASE an enzymatic concentrate derived from the porcine pancreas gland, available in powder or tablet form.  Made by Axcan Pharma, 800-950-8085

(plant enzymes may be attempted to use for EPI dogs with severe allergies to porcine enzymes) TOTAL-ENZYMES In some cases, a dog may have pork-based allergies, or meat protein allergies. If so, you may want to try an alternative plant-based enzyme. But please realize... plant enzymes are "supplements", EPI dogs need "replacement enzymes" however, if you have to use plant enzymes because your EPI dog medically cannot tolerate pork enzymes, there have been some EPI cases (not all) that have had success using this product. At the very least, you will need to double the recommended dose. We always advise against plant enzymes, but sometimes there are situations where porcine-based enzymes are not an option.  If you click on this PetEnzymes icon it will take you directly to their site:
pet enzymes

Enzyme conversion information


  • USP = United States Pharmacopeia
  • BP = British Pharmacopoeial 
  • FIP = Fédération Internationale Pharmaceutique
  • PhEur = European Pharmacopoeia

 conversion from FIP/PhEur units to USP units as follows: 

  • for lipase, 1 FIP/PhEur unit = 1 USP unit;
  • for amylase, 1 FIP/PhEur unit = 4.15 USP units;
  • for protease, 1 FIP/PhEur unit = 62.5 USP units
  • for lipase, 1BP/PhEur unit = 1 USP unit;
  • for amylase, 1 BP/PhEur unit = 4.15 USP units;
  • for protease, 1 BP/PhEur unit = 62.5 USP units

Enzymes available in the UK - November 2012  

A few weeks ago, we were approached by a company called Chemeyes http://www.chemeyes.co.uk/


They had successfully sourced a pancreatin powder for use with their own dog, "Dizzy" (the directors of the company have a pharmaceutical background) as they were struggling to find an alternative to the Tryplase enzyme. The Chemeyes porcine pancreatic enzyme strength is as follows:


Lipase 20,000  BP units
Protease 1,400  BP units
Amylase 24,000  BP units


To further accommodate EPI customers, a running updated enzyme "certificate of analysis" will be posted on the Chemeyes website for each batch of enzymes.


Not only is this a good substitute for Tryplase, it also will interest those people in the UK that formerly used the Vet V powder and now use pancreatin powder. The powder is sold and pre-packed like Tryplase or as a powder.  The costs are as follows and they are significantly lower than the comparable products in the powder format:


50 capsules  -  £ 16

100 capsules -  £ 18

250 capsules -  £ 42

500 capsules -  £ 78 



50 grams - £ 12

250 grams - £ 40

500 grams - £ 85

1 kg - £ 150

5kg - £ 450


The pancreatin powder which appears to be the replacement for the Vet V powder is only 15,000 Lipase but costs out at 22p per gram whereas the 250 gram tub of Chemeyes costs in at 16p per gram on a stronger product.


The details of the Chemeyes product will now be included in the "Managing EPI in the UK" brochure which is included in the download section of this website.


Some of our epi4dogs members, Ann with Maddie, and Jackie with Tyler, have both used this enzyme for their dogs over the last 10 days and can confirm it's effectiveness.


Cameron, who runs Chemeyes, is also looking at extending the product base and at the moment this will include a pre-biotic and a B12 pill/capsule that will include the Intrinsic Factor for our EPI pets similar to the WonderLabs "Trinfac" product that folks in the USA use.  If you have any questions, please feel free to contact Cameron at Chemeyes directly.  He will also keep us informed of any new products being considered.


This powdered enzyme product can also be exported to the EU and India which will hopefully be another option for our fellow members.

To contact Cameron directly, write to:   [email protected]

The company's website is:   http://www.chemeyes.co.uk/ 


European Enzyme products potency & Tylan metric guide

Pancrex Granules (1g=1ml)
Pancreatin BP to provide enzymatic activity per gram not less than:
Free protease             300 BP units (5ml = 1500)
Lipase                        5000  BP units (5ml = 25000)
Amylase                     4000 BP units (5ml = 20000)

Pancreatin BP to provide enzymatic activity per capsule not less than:
Free protease               1200 BP units
Lipase                          30000 BP units
Amylase                       18750 BP units

Panzym (1g= 1ml)
Pancreatin BP to provide enzymatic activity per gram not less than:
Free protease                2100 BP units
Lipase                           38000 BP units
Amylase                        32500 BP units

Pancrex V Capsules
Pancreatin BP to provide enzymatic activity per capsule not less than:
Free protease                 430 BP units
Lipase                            8000 BP units
Amylase                         9000 BP units

Pancrex V Capsules 125 mg
Pancreatin BP to provide enzymatic activity per capsule not less than:
Free protease                 160 BP units
Lipase                            2950 BP units
Amylase                         3300 BP units

Pancrex V Forte Tablets
Pancreatin BP to provide enzymatic activity per tablet not less than:
Free protease                  330 BP units
Lipase                             5600 BP units
Amylase                          5000 BP units

Pancreatin BP to provide enzymatic activity per capsule not less than:
Free protease                  450 BP units
Lipase                             13000 BP units
Amylase                          9000 BP units

Creon 10
Pancreatin BP to provide enzymatic activity per capsule not less than:
Free protease                  600 BP units
Lipase                             10000 BP units
Amylase                          8000 BP units

Creon 25
Pancreatin BP to provide enzymatic activity per capsule not less than:
Free protease                  1000 BP units
Lipase                             25000 BP units
Amylase                          18000 BP units

Tylan Dosage guide:
13kg/30 lb - 1/8 tsp
27kg/60 lb - 1/4 tsp
41kg/90 lb - 3/8 tsp
54kg/120 lb - 1/2 tsp
twice per day

FDA report on CREON

For those who do not have access to porcine powdered enzymes but do have access to CREON and are interested in learning more about it (enteric coated capsules)....you might be interested in the following USA FDA regulations just approved CREON for human consumption on May 2009 for the use in the USA for in Exocrine Pancreatic Insufficiency http://www.fda.gov/

In accordance with using CREON ... in July 2012 ...the results of a UK study of using enteric coated enzymes (this is what CREON is) for dogs with EPI is listed below the FDA CREON information... 


May 7, 2009

Media Inquiries:
Rita Chappelle, 301-796-4672
Consumer Inquiries:

FDA Approves Pancreatic Enzyme Replacement Product for Marketing in United States
Creon designed to help those with cystic fibrosis, others with exocrine pancreatic insufficiency

The U.S. Food and Drug Administration announced today that it has approved Creon (pancrelipase), a pancreatic enzyme replacement product designed to help patients with cystic fibrosis and others with exocrine pancreatic insufficiency (EPI) digest and absorb nutrients from foods. Creon is the first FDA-approved delayed-release pancreatic enzyme replacement product to be marketed in the United States as a result of the agency's unapproved drugs initiative.

Creon, which contains a mixture of digestive enzymes extracted from the pancreas of pigs, helps patients lacking the enzymes needed to digest fats, proteins and sugars from food. Creon is approved for use in pediatric and adult patients.

The FDA had required the manufacturer of Creon to submit, and the agency has approved, a Risk Evaluation and Mitigation Strategy (REMS), which includes a Medication Guide, to advise patients on risks associated with high doses of Creon, and the theroretical risk of transmission of viral disease from pigs to patients. A rare bowel disorder, called fibrosing colonopathy, can result from a patient's high-dose use of Creon. While this condition is serious and may require surgery, a patients' chances of having this condition may be reduced through their adherence to dosing instructions in the labeling. 

The risks of a rare bowel disorder and viral transmission described in the Medication Guide are considered to be risks related to all porcine (pig)-derived pancreatic enzyme products, including Creon.

Instructions for dosing based on weight and age should be followed carefully. Creon may be sprinkled on food. Because Creon is a delayed-release drug, patients should never crush or chew the capsule as this would cause an early release of the enzymes and a reduction in enzyme activity.

“The approval of Creon will allow patients to have access to an approved pancreatic enzyme replacement product that meets FDA standards for effectiveness, safety, and manufacturing consistency,” said Donna Griebel, M.D., director, Division of Gastroenterology Products within FDA's Center for Drug Evaluation and Research (CDER).

The FDA's Office of Compliance and Office of New Drugs within CDER worked with Creon's manufacturer, Solvay Pharmaceuticals, through the agency's unapproved drugs initiative to help the company come into compliance with federal laws by obtaining FDA approval. The agency continues to encourage the manufacturers of all other unapproved pancreatic enzyme products (PEPs) to work with the agency to obtain market approval. All PEPs must obtain FDA approval by April 28, 2010, or be removed from the marketplace.

“Like other medically necessary drugs, the FDA is exercising its enforcement discretion while it works with the manufacturer toward gaining approval of these drugs,” said Deborah Autor, director, Office of Compliance, CDER. “FDA approval is critical, and the manufacturers of these products have a responsibility to the American public to ensure that patients have drugs that meet our standards of safety, effectiveness, quality, and labeling.”

People who are allergic to pork and pork products, suffer from gout or kidney disease, have difficulty swallowing, are pregnant or who plan to become pregnant, or are breastfeeding, should discuss the use of Creon with their health care professional.  Common side effects of Creon include flatulence (gassiness), abdominal pain, headache, and dizziness.

Creon and other pancreatic enzyme products are made from pancreatic organs of pigs used for food. There is a theoretical risk of contracting a viral infection from pig-derived medicines, but no human illness has been reported.

Health care professionals and consumers may report serious adverse events (side effects) or product quality problems with the use of this product to the FDA's MedWatch Adverse Event Reporting program either online, by regular mail, fax or phone.

  • Online
  • Regular Mail: use postage-paid FDA form 3500 and mail to MedWatch, 5600 Fishers Lane, Rockville, MD 20852-9787
  • Fax: 800-FDA-0178
  • Phone: 800-FDA-1088 
  • For more information on Creon, visit FDA's Web site.
A blinded randomized controlled trial to determine the effect of enteric coating
on enzyme treatment for canine exocrine pancreatic efficiency:       JULY 2012,   UK study


A blinded randomised controlled trial to determine the effect of enteric coating on enzyme treatment for canine exocrine pancreatic efficiency

Aran Mas, Peter-John M Noble, Peter J Cripps, Daniel J Batchelor, Peter Graham and Alexander J German


For all author emails, please log on.

BMC Veterinary Research 2012, 8:127 doi:10.1186/1746-6148-8-127

Published: 28 July 2012

Abstract (provisional)


Enzyme treatment is the mainstay for management of exocrine pancreatic insufficiency (EPI) in dogs. 'Enteric-coated' preparations have been developed to protect the enzyme from degradation in the stomach, but their efficacy has not been critically evaluated. The hypothesis of the current study was that enteric coating would have no effect on the efficacy of pancreatic enzyme treatment for dogs with EPI. Thirty-eight client-owned dogs with naturally occurring EPI were included in this multicentre, blinded, randomised controlled trial. Dogs received either an enteric-coated enzyme preparation (test treatment) or an identical preparation without the enteric coating (control treatment) over a period of 56 days.


There were no significant differences in either signalment or cobalamin status (where cobalamin deficient or not) between the dogs on the test and control treatments. Body weight and body condition score increased in both groups during the trial (P<0.001) but the magnitude of increase was greater for the test treatment compared with the control treatment (P<0.001). By day 56, mean body weight increase was 17% (95% confidence interval 11-23%) in the test treatment group and 9% (95% confidence interval 4-15%) in the control treatment group. The dose of enzyme required increased over time (P<0.001) but there was no significant difference between treatments at any time point (P=0.225). Clinical disease severity score decreased over time for both groups (P=0.011) and no difference was noted between groups (P=0.869). No significant adverse effects were reported, for either treatment, for the duration of the trial.


Enteric coating a pancreatic enzyme treatment improves response in canine EPI.

The complete article is available as a provisional PDF. The fully formatted PDF and HTML versions are in production.



Feb 2017:  by Dr. Anne Moesseler .... Amylase and Protease replacement enzymes needed in higher quantity than what was previously thought!

To read the entire research on Fate of Fat, Protein & Starch (below) please click on this link: http://www.mdpi.com/2072-6643/9/2/150/htm

May 20, 2017


Reference for the above research:  


" Dog Gastric Lipase: Stimulation of Its Secretion In Vivo and Cytolocalization in Mucous Pit Cells FREDERIC CARRIGRE, VBRONIQUE RAPHEL, HERVE MOREAU, ALAIN BERNADAC, MARIE-ALIX DEVAUX, ROBERT GRIMAUD, JAMES A. BARROWMAN, CLAUDE BENICOURT, JEAN-LOUIS JUNIEN, RENfi LAUGIER, and ROBERT VERGER Centre de Biochimie et de Biologie Mokulaire du Centre National de la Recherche Scientifique, Marseille:

U-315 de l’INSERM, Marseille: and Institut de Recherche jouveinal, Fresnes, France

GASTROENTEROLOGY 1992;102:1535-1545

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