Current EPI Research - The Maya Metabolomic Study


The Maya Metabolomic Study

 in Honor of Maya, an esteemed member of Epi4Dogs

 Epi4Dogs is pleased to announce that we are collaborating with Dr. David A. Williams and Dr. Patrick Barko of the College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Champaign, Illinois. Together we are embarking upon a new research study, the Maya Metabolomic Studyhttp://vetmed.illinois.edu/cmmi/  in their Clinical Metabolomics and Microbiomics Initiative to further investigate possible environmental factors that may be involved in EPI. Metabolomics is an emerging field in which a very large number of small chemicals can be analyzed from samples of body fluids and tissues. This new technology has the potential to identify previously undetectable abnormalities associated with development of various diseases, including EPI, and it is hoped that this new information will provide clues as to why this disease develops and what we can do to prevent it.

We know that there are some genetic indications with EPI in dogs from the research done by Dr. Leigh Anne Clark of Clemson University Genetics and that it is strongly suspected that EPI is a combination of both genetics and environmental causes. The Maya Metabolomic Study will hopefully help to identify the environmental “trigger(s)” as to why EPI occurs and what causes the acinar cells in the pancreas to start destroying themselves.

To learn more about the complex field of metabolomics technology, interested readers can go to Metabolon’s website section that succinctly explains the study of metabolism and the metabolomics research process: http://www.metabolon.com/technology/about-metabolomics.aspx  and http://www.metabolon.com/technology/the-science-of-metabolism.aspx

Participation in this study will require one or two short visits to your veterinarian, or at a designated and authorized location, where samples of blood, feces, urine, and DNA will be collected by trained veterinary professionals. These samples will be shipped to or collected by Dr. Barko for analysis.

To find out if your dog qualifies for participation, you will need to fill out the EPI REGISTRY located here:  http://www.epi4dogs.com/epiregistry.htm (even if you filled it out a few years ago, please feel free to fill it out again, as i have recently included additional features to benefit the study).  Dr. Barko will sort the database in various ways as there are multi-levels of candidates needed for the study, and he will contact those via email who fit the criteria. This will be an on-going process. 

Never before has such an all inclusive/comprehensive EPI study been undertaken with every single body fluid collected. This will allow for further testing to be pursued with samples already on hand based on these study results. This was never possible before and a huge thank you to Dr. Patrick Barko for working diligently getting everything properly set-up for this extraordinarily comprehensive study!

I would like to especially and gratefully thank Maya’s family along with Drs. Williams and Barko. Because of each of them, this study is now possible.  And I would like to further extend a thank you to the University if Illinois, Toby's family, and the entire membership of Epi4Dogs for contributing much needed data for this study submitted on the Epi4Dogs “EPI Registry.” Again, Thank You!!!   

         The Research Investigators


Dr. Patrick Barko                                     Dr. David A. Williams
Veterinary Resident                                    MA VetMB PhD, Diplomate ACVIM, ECVIM-CA
Veterinary Clinical Medicine                       Professor in Small Animal Internal Medicine
College of Veterinary Medicine                   College of Veterinary Medicine
University of Illinois Urbana-Champaign            University of Illinois Urbana-Champaign
Champaign, Illinois                                 Champaign, Illinois 

Dr. Williams Biography

Dr. David A Williams is a Professor of Veterinary Clinical Medicine at College of Veterinary Medicine, University of Illinois. He founded the "GI Lab" in 1985 at the University of Florida, when he introduced assay of serum trypsin-like immunoreactivity (TLI) in the dog to the United States. His research has been focused on the development and application of new tests for gastrointestinal diseases, particularly those affecting the pancreas, small intestine, stomach and liver of dogs and cats. Students and staff working in his subsequent GI Laboratories at Kansas State, Purdue, and most recently Texas A&M Universities established several other novel tests for gastrointestinal diseases for use by veterinarians internationally. These included feline serum TLI, canine and feline serum PLI, canine and feline fecal alpha 1 -proteinase inhibitor, unconjugated serum bile acids, canine TSH, and canine and feline serum cobalamin and folate assays. He received his veterinary degree from the University of Cambridge and his PhD from the University of Liverpool (where he first developed the canine TLI assay). He was an intern and resident at the University of Pennsylvania, and has held Faculty positions at the University of Florida, Kansas State University, Purdue University, Texas A&M University, and the University of Illinois, where he is presently Head of the Department of Veterinary Clinical Medicine. He continues to work as a consultant with the GI Lab, providing telephone consultations regarding management of patients diagnosed using the GI Lab services.

Research Interest

Dr. David A Williams's research interests are Development and application of new tests for gastrointestinal diseases, particularly those affecting the pancreas, small intestine, stomach and liver of dogs and cats.


THANK YOU !!!!        

Olesia C. Kennedy, President

Epi4Dogs Foundation, Inc.  



  Please consider supporting EPI Awareness and the EPI Maya Metabolomic Research by making a donation to Epi4Dogs Foundation Inc a 501c3 Non-Profit Public Charity: 
consider donating by participating in an Epi4Dogs fund raiser  http://www.epi4dogs.com/epiproducts.htm 

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