Long-Term Tylan use

Epi4Dogs Foundation Inc.’s mission is the advancement of science and education relating to EPI (Exocrine Pancreatic Insufficiency), yielding useful insights and positive outcomes in better managing EPI in dogs and cats. Our goals are to support and/or collaborate with veterinary EPI research and researchers, and to promote EPI awareness by educating the general public, pet owners, pet organizations, rescue and shelter organizations, veterinary schools and veterinarians.
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Paige's Guardian
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Posts: 49
Country: United States
State: Arizona

Long-Term Tylan use

Post by Paige's Guardian » 02 Mar 2019, 12:37

Paige has never needed Tylan prior to July 2018. She had a bad episode of Pancreatitis which was probably brewing for awhile. During that tx, she needed Tylan for the first time to normalize her stools. Her stools have been 100% normal since starting on enzymes at 9 months of age. She will be 8 yo in a couple of months.

Paige is now on her 3rd round of Tylan in the past 8 months. She is on it for the 45 days, then tapers off. She is on the correct dose for a 100# dog at 3/8 tsp, 2x/day with meals. It works immediately to normalize her stools.

Now, I am wondering if she should just stay on the Tylan long term at a low dose to prevent SID from returning....

What do you guys think?

Conny
Paige's Guardian (Conny)

Paige, 8-year old Great Dane.

Dx: Malabsorption at age 9 months of age. Low Folate. On plant enzymes for 1.5 years. Experienced bloat 2x and Pancreatitis. Switched to Enzyme Diane. TLI tested but never low. Diarrhea when off enzymes.
06/2019--cPL <50 (normal) SID-Tylan 3/8 tsp 2x/day. 1 tsp Pancreatin 6x per meal. Royal Canon Hydrolyzed Protein Dry Food

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jilbert57
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Country: United States
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Re: Long-Term Tylan use

Post by jilbert57 » 02 Mar 2019, 12:55

Hi Conny, I would find the lowest dose Tylan that keeps the poops solid. I did this with Mickey. I wish I would have known more about Slippery Elm with him I would have experimented a little.
I forgot, have you used SE?
My name is Jill and we live on the Hood Canal in Washington State. We currently have 2 Jack russells, TJ is 8 and Sadie is 2.

Mickey and his pancreatitis brought me to Epi4dogs.com site in 2012 to help manage it.
He lived from 6/99 - 8/2014

Mickey, Jack Russell. Chronic Pancreatitis. Dianes enzymes, 1/8t 3x/day with meals.

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Olesia711
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Location: North Carolina
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My name: olesia

Re: Long-Term Tylan use

Post by Olesia711 » 02 Mar 2019, 16:05

Hi Conny

Jill gave you a great suggestion.....when the 3rd course of Tylan is complete.. instead of stopping completely you can try tapering down the Tylan dose (reduce in half morning & night) and after a week, try tapering this dose down to the half dose just once a day - -stay on this low maintenance dose and see if this is enough to stabilize the SID

OR

Start tapering down the Tylan... but also add slippery elm with each meal.... continue to taper down the Tylan .... 1/2 morning & night, and then the next week, give just that 1/2 dose Tylan daily, and then go to 1/2 dose Tylan every other day (for another week) and then give Tylan just twice a week for the final week... all the while you have her on the Slippery with each meal.....so when you stop after the final week of Tylan.... watch the poos and closly and listen to the gut ..... for any signs of SID getting out of control again..... and hopefully by giving the Slippery Elm while doing all this slow taper with the Tylan and then once of the Tylan completely done.... Hopefully..... the Slippery Elm is doing a good enough job so that she doesn't need to go back on the Tylan.................
Olesia, was owned by Izzy, a 35lb Spanish Water Dog (SWD), Diagnosed at 1.5 years old - TLI results 1.. Izzy passed away on February 13, 2020 at 15 years old. She lived with EPI for 13+1/2 years. It was because of Izzy that Epi4Dogs was started... she was the inspiration. May her legacy of helping others with EPI continue for as long as needed.........

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Jean
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Location: South Liverpool
Country: United Kingdom - England
Pet name: Kara, lost 10th May 2019
My name: Jean

Re: Long-Term Tylan use

Post by Jean » 03 Mar 2019, 04:26

we have never been able to stop Tylan, Kara just goes downhill immediately, i brought this up with the University vets, and they said that because of the immune system being so compromised, basically you do what you have to,Kara is on 1/8th teaspoon twice daily, but they are all different
My name is Jean we live in Liverpool in Uk

I am the Forum Director which I am very proud of

My Kara born 21 July 2009 diagnosed with EPI by cTLI test August 2010 TLI = <1...folate 14 Cobalamin 408, shot down to 94, b12 injections every other day

Lowest weight 39 pounds

We used Panzym enzymes, Tylan and Chemeyes b12 capsules

Sadly, on 10th May 2019, we lost her to DM


Jeanx

Paige's Guardian
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Posts: 49
Country: United States
State: Arizona

Re: Long-Term Tylan use

Post by Paige's Guardian » 04 Mar 2019, 07:45

My main issue that I am not sure about is that I can taper her completely off the Tylan with normal stools. She is ok for about 6-8 weeks; then, symptoms all start to slowly come back.

I have slippery elm but she is so sensitive that I really don't want to introduce anything else. She still is not on a normal diet. I haven't been able to get her back on regular dog food. I am grateful she loves boiled chicken breast and it's been on sale. The butcher looks at me funny when I ask for 40 pounds!

I think that when I taper her, I will just keep her on a low dose 1x/day. Tylan is not too expensive, covered by insurance and vet at this point just approves prescriptions.
Paige's Guardian (Conny)

Paige, 8-year old Great Dane.

Dx: Malabsorption at age 9 months of age. Low Folate. On plant enzymes for 1.5 years. Experienced bloat 2x and Pancreatitis. Switched to Enzyme Diane. TLI tested but never low. Diarrhea when off enzymes.
06/2019--cPL <50 (normal) SID-Tylan 3/8 tsp 2x/day. 1 tsp Pancreatin 6x per meal. Royal Canon Hydrolyzed Protein Dry Food

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Jean
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Posts: 1707
Location: South Liverpool
Country: United Kingdom - England
Pet name: Kara, lost 10th May 2019
My name: Jean

Re: Long-Term Tylan use

Post by Jean » 04 Mar 2019, 13:21

its what we did Conny, good luck

its the luck of the draw, some cope some dont

j
My name is Jean we live in Liverpool in Uk

I am the Forum Director which I am very proud of

My Kara born 21 July 2009 diagnosed with EPI by cTLI test August 2010 TLI = <1...folate 14 Cobalamin 408, shot down to 94, b12 injections every other day

Lowest weight 39 pounds

We used Panzym enzymes, Tylan and Chemeyes b12 capsules

Sadly, on 10th May 2019, we lost her to DM


Jeanx

Barb
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Country: United States
State: New Jersey

Re: Long-Term Tylan use

Post by Barb » 04 Mar 2019, 13:44

Yes, we could never get beyond two weeks without tylan. Then the symptoms would appear again. It just depends on the dog.

Barb

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Madelon
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Re: Long-Term Tylan use

Post by Madelon » 04 Mar 2019, 22:11

Some do require a very low maintenance dose of Tylan for life. I give Doc 1/2tsp of Slippery Elm Bark Powder twice a day with his meals - he will get it for life. You might just give it a try if you already have it on hand - if it doesn't work then you can go back to the Tylan.
Madelon, owned by DOC. DOC dx EPI 5/2015 = TLI < .4, B12 406; Folate >24. DOC taught me so much and together we battled and overcame EPI, food sensitivies, environmental allergies but we lost the cancer battle. DOC was dx with hemangiosarcoma 5/2022 and crossed the rainbow bridge July 24, 2022. He is and always will be the love of my life, my soulmate, my heart dog.

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Lisabel
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Country: United States
State: Pennsylvania
Pet name: Abby

Re: Long-Term Tylan use

Post by Lisabel » 12 Apr 2019, 14:09

Hi Connie... my Abby was on 1 compounded capsule (approx. 1/9tsp) of Tylan twice a day after her meals. In the beginning we tried a few times to wean her off but the poops turned awful every time. She was around 75lbs and that small dose kept everything in check for years. All of our pups are different and sometimes the dosages need a little tweaking but stick with it..... Lisa

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