Monoclonal Antibody Meds ok for epi dogs?

[Greyden]

Hello!

We have had our Non-EPI dog on Librela for arthritis for a while and he is doing great!
Our other Non-EPI dog has had Cytopoint for allergies and responded extremely well.
Both are monoclonal antibody meds.
Has anyone used these or other m a meds with their EPI dog? Are there contraindications?
Dot appears to have some allergy going on and possible arthritis and we are thinking they might be helpful. But we don't want to wreck the EPI progress we've made.
So, if you know something about giving an EPI dog a monoclonal antibody med please share your experience, research and/or knowledge.

Thank you!

[Chance]

Technically, there's no contraindications for Librela or Cytopoint in EPI dogs. However, both of these meds have had very catastrophic results in dogs in general. With either one, sometimes it's within days of the first injection that severe neurological symptoms present, sometimes leading to death. Sometimes it's the first injection; sometimes it's the 2nd, 4th or maybe the 14th injection. It's Russian Roulette.

There's pages on both Cytopoint the truth, and Librela the truth.

Consider that both of these drugs were in clinical trials for human use. Interleukin inhibitors was hoped to be the best thing for diseases like psoriasis. Clinical trials were halted many years ago because of troubling effects. Tanezumab was the human equivalent for Librela. This was also banned due to serious side effects. So both drugs are banned in human use because of their potentially deadly side effects. Yet they are allowed in animal use.

If dogs are suffering, and will have a very poor quality of life; I absolutely understand doing anything possible to save them. So I'm not trying to pass judgment. I'm just letting you know that they are not as safe as some vets would have you believe.

[jilbert57]

I agree with Chance on the catastrophic results those 2 injections have had for a number of animals.
I know FB can be a hodgepodge of misinformation but look up some groups and lurk lol.
My pups always did great with Adequan for arthritis. I gave at home.

Jill

[Greyden]

Thank you both for your replies.
I found the article below. It has its own bias but was insightful as to how Librela works. There is also an article on Cytopoint which I have not yet read.

https://www.dogsnaturallymagazine.com/l ... he-making/

We will not be giving it to Dot under any circumstances! She has had seizures - the last round 7 days after receiving tape worm med. There are also implications for the pancreas. Not going there! Enough trouble already.

Rethinking using for Bob and will be watching him closely as he just had a dose yesterday. He has had such good energy the last couple weeks - now I'm not sure if that was Librela wearing off or cooler weather or tweaking food or Librela being effective.

My vet friend loves these meds and raves about how safe they are. Will be forwarding her the article as well.

Thanks again for your help!

[jilbert57]

Gwen, thank you for researching into our concerns for these two drugs.

Jill

[Eddiespaghetti]

I have been looking into too. From what I can tell there are tragedies involved.
It seems to have the same rules as Prednisone. Can't be given with nsaids and definitely don't want to give it with history of kidney disease.
As someone who just lost a sweet baby to a brain tumor, it is insane how quickly they can deteriorate while showing no symptoms. Now, I am not saying those medications didn't cause or make worse other issues, I am only saying it is quite possible those deaths already had major issues while presenting little to no symptoms.
I am also not trying to change your mind in no way. I know you will do what is best for your family. I just wanted to say for 90% of medications that get approved, they do go through rigorous testing and trials. I do hope your and your puppos find what they need to thrive.